Detalhe da pesquisa
1.
A phase 1 study of triple-targeted therapy with BRAF, MEK, and AKT inhibitors for patients with BRAF-mutated cancers.
Cancer
; 2024 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38261444
2.
The INGENIOUS trial: Impact of pharmacogenetic testing on adverse events in a pragmatic clinical trial.
Pharmacogenomics J
; 23(6): 169-177, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37689822
3.
Influence of CYP2B6 Pharmacogenetics on Stereoselective Inhibition and Induction of Bupropion Metabolism by Efavirenz in Healthy Volunteers.
J Pharmacol Exp Ther
; 2022 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35798386
4.
A New Data Repository for Pharmacokinetic Natural Product-Drug Interactions: From Chemical Characterization to Clinical Studies.
Drug Metab Dispos
; 48(10): 1104-1112, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32601103
5.
Influence of Uridine Diphosphate Glucuronosyltransferase Family 1 Member A1 and Solute Carrier Organic Anion Transporter Family 1 Member B1 Polymorphisms and Efavirenz on Bilirubin Disposition in Healthy Volunteers.
Drug Metab Dispos
; 48(3): 169-175, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31888882
6.
Mechanistic Assessment of Extrahepatic Contributions to Glucuronidation of Integrase Strand Transfer Inhibitors.
Drug Metab Dispos
; 47(5): 535-544, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30804050
7.
Chiral Plasma Pharmacokinetics and Urinary Excretion of Bupropion and Metabolites in Healthy Volunteers.
J Pharmacol Exp Ther
; 358(2): 230-8, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27255113
8.
Stereoselective Glucuronidation of Bupropion Metabolites In Vitro and In Vivo.
Drug Metab Dispos
; 44(4): 544-53, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26802129
9.
Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural Product-Drug Interaction.
Drug Metab Dispos
; 43(9): 1353-9, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26070840
10.
Chemoenzymatic Synthesis, Characterization, and Scale-Up of Milk Thistle Flavonolignan Glucuronides.
Drug Metab Dispos
; 43(11): 1734-43, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26316643
11.
Identification of diet-derived constituents as potent inhibitors of intestinal glucuronidation.
Drug Metab Dispos
; 42(10): 1675-83, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25008344
12.
Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle.
Bioorg Med Chem
; 21(13): 3919-26, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23673225
13.
Pharmacogenetics and Practice: Tailoring Prescribing for Safety and Effectiveness.
J Nurse Pract
; 14(10): 697-704.e1, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30555285
14.
Circulating miRNAs as Biomarkers for CYP2B6 Enzyme Activity.
Clin Pharmacol Ther
; 109(2): 485-493, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32772362
15.
Mass balance and pharmacokinetics of an oral dose of 14 C-napabucasin in healthy adult male subjects.
Pharmacol Res Perspect
; 9(1): e00722, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33576192
16.
Probenecid-Boosted Tenofovir: A Physiologically-Based Pharmacokinetic Model-Informed Strategy for On-Demand HIV Preexposure Prophylaxis.
CPT Pharmacometrics Syst Pharmacol
; 9(1): 40-47, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31749296
17.
Inhibitory Effects of Probenecid on Pharmacokinetics of Tenofovir Disoproxil Fumarate and Emtricitabine for On-Demand HIV Preexposure Prophylaxis.
Clin Pharmacol Ther
; 107(5): 1200-1208, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31675437
18.
Drug-gene and drug-drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial.
Pharmacogenomics
; 20(6): 397-408, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30784356
19.
Rifampin modulation of xeno- and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes.
Pharmacol Res Perspect
; 6(2): e00386, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29610665
20.
Variants in the CYP2B6 3'UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs.
Clin Pharmacol Ther
; 104(1): 130-138, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28960269